MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a 16-amino-acid peptide encoded within the mitochondrial genome — a discovery that reshaped how researchers view mitochondria, positioning them as more than purely energy-producing organelles. Since its identification, MOTS-c has been studied as a mitochondrial-derived peptide (MDP) that appears to act as a systemic signalling molecule, with reported effects extending beyond the mitochondrion itself.

Research has examined MOTS-c in the context of cellular energy regulation, in particular its reported activation of AMPK — a master regulator of cellular energy homeostasis. Studies in pre-clinical models have explored how MOTS-c relates to glucose metabolism, fatty-acid oxidation pathways, and mitochondrial dynamics. Its capacity to translocate to the nucleus under conditions of cellular stress and to influence gene transcription has made it a subject of interest in mitochondrial biology and ageing research.

MOTS-c has also been investigated under conditions of metabolic stress, in exercise-physiology models, and in relation to cellular senescence — contexts in which mitochondrial signalling plays a documented role. It sits within a broader research movement aimed at understanding how mitochondrial-derived peptides communicate with the wider cell and organism.

myPEPT supplies MOTS-c at ≥99% verified purity (CAS 1627580-64-6) with a Certificate of Analysis from independent laboratory testing. Each 10 mg vial is supplied lyophilized and shipped across the EU in research-grade packaging.

What researchers should know: MOTS-c is a research peptide supplied strictly for laboratory use. It is not approved for human use and is not a therapeutic compound — not for human consumption or injection. Always handle it in accordance with your institution's safety and research protocols.