NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme involved in hundreds of enzymatic reactions across cellular metabolism. It plays a central role as an electron carrier in cellular respiration, and serves as a substrate for a family of enzymes — including sirtuins and PARPs — that regulate gene expression, DNA repair, and stress responses. Its decline with age has made it one of the most intensively researched molecules in the cellular aging and metabolic biology fields.

Research has focused heavily on NAD+'s role in sirtuin activation, particularly SIRT1 and SIRT3, which are NAD+-dependent deacetylases linked to mitochondrial biogenesis, cellular stress resistance, and epigenetic regulation. Studies have explored how NAD+ availability influences these pathways in aging cell models and metabolically active tissues.

NAD+ research also extends to the PARP family of DNA repair enzymes, which consume NAD+ during the repair of DNA strand breaks. Understanding how NAD+ metabolism intersects with DNA maintenance pathways is an active area of research in both oncology-related models and aging biology. Researchers also study NAD+ precursors (NMN, NR) in relation to intracellular NAD+ replenishment.

myPEPT supplies NAD+ at ≥99% verified purity with a Certificate of Analysis from independent lab testing. Shipped across the EU in research-grade packaging designed to maintain compound stability.

What researchers should know: NAD+ in this form is supplied for laboratory research use only. It is not a dietary supplement and is not intended for human consumption in this format. Handle and store in accordance with your institution's research compound protocols.