KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH), one of the naturally occurring melanocortin peptides. While alpha-MSH has multiple known functions, research has focused on KPV specifically for its role in inflammatory signaling — particularly its interactions with intracellular pathways that regulate cytokine production.

Research has explored KPV's effect on NF-kB signaling, a central transcription factor pathway involved in pro-inflammatory cytokine expression. Studies have looked at its interaction with inflammatory mediators in cell culture and pre-clinical models, including gastrointestinal tissue models where inflammatory regulation is an active area of study. Its small size and relatively simple structure make it an accessible research tool for peptide biology labs.

The compound has also been investigated in models examining skin and mucosal inflammation, where melanocortin receptor-mediated pathways play a documented regulatory role. KPV research sits at the intersection of melanocortin biology, immunology, and gut physiology.

myPEPT supplies KPV peptide at ≥99% verified purity with a Certificate of Analysis from independent third-party testing. Lyophilized and shipped across the EU in properly sealed research-grade vials.

What researchers should know: KPV is supplied for laboratory research purposes only. It is not a therapeutic or pharmaceutical product and is not approved for human use in this format. Handle and store in accordance with your institution's protocols for research peptides.