SS-31, also known as Elamipretide or MTP-131, is a synthetic tetrapeptide belonging to the Szeto-Schiller peptide family, designed to selectively target the inner mitochondrial membrane. Its mechanism of action centers on its interaction with cardiolipin — a phospholipid unique to the inner mitochondrial membrane that plays a structural and functional role in the electron transport chain and ATP synthase activity.

Research has explored SS-31's effects on mitochondrial membrane potential, cristae architecture, and electron transport chain efficiency in pre-clinical models. Studies have investigated how cardiolipin interaction influences cytochrome c binding and the structural organization of respiratory supercomplexes — questions central to understanding mitochondrial bioenergetics at the molecular level.

SS-31 has also been studied in models examining ischemia-reperfusion injury biology, heart failure-related mitochondrial dysfunction, and aging-associated bioenergetic decline, where mitochondrial membrane integrity is a key variable. Its combination of membrane targeting and bioenergetic relevance has made it one of the more widely cited compounds in mitochondria-targeted peptide research.

myPEPT supplies SS-31 at ≥99% verified purity with a Certificate of Analysis from independent lab testing. Lyophilized and shipped across the EU in research-grade packaging.

What researchers should know: SS-31 (Elamipretide) is a research peptide supplied for laboratory use only. It is not approved for unsupervised human use in this format. Handle and store in accordance with your institution's protocols for mitochondria-targeted research compounds.