Melanotan II is a synthetic cyclic analog of alpha-melanocyte-stimulating hormone (alpha-MSH), designed with structural modifications that increase its binding affinity at melanocortin receptors compared to the native peptide. It acts on multiple melanocortin receptor subtypes — including MC1R, MC3R, MC4R, and MC5R — making it a useful pharmacological probe in receptor biology research.

Research has explored Melanotan II as a tool for investigating melanocortin receptor pharmacology, including binding kinetics, receptor selectivity, and downstream intracellular signaling cascades such as cAMP pathway activation. Studies using MT-2 have helped characterize the functional roles of individual melanocortin receptor subtypes in pre-clinical models, contributing to broader understanding of the melanocortin system.

Researchers have also studied Melanotan II in models examining neuroendocrine signaling and autonomic nervous system regulation, where MC4R plays a documented role. Its broad receptor activity profile has made it a frequently cited reference compound in melanocortin peptide pharmacology literature.

myPEPT supplies Melanotan II at ≥99% verified purity with a Certificate of Analysis from independent third-party lab testing. Lyophilized and shipped across the EU in properly sealed research vials.

What researchers should know: Melanotan II (MT-2) is supplied strictly for laboratory research use. It is not approved for human use and is not a therapeutic or cosmetic product in this format. Handle and store in accordance with your institution's protocols and all applicable regulations regarding research peptides.